Why the study?
Does Thioredoxin 1 and miR-98/let-7 expression reduce Angiotensin II-induced cardiac hypertrophy in preclinical models?
Does Thioredoxin 1 and miR-98/let-7 expression reduce Angiotensin II-induced cardiac hypertrophy in preclinical models?
Thioredoxin 1 exerts antihypertrophic effects in the heart by upregulating miR-98 and the let-7 family, which subsequently downregulate cyclin D2.
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Does not support clinical adoption; leaves open therapeutic targeting of Trx1-miR-98 in hypertrophy.
Yang et al. (2010) studied this question.
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