September 28, 2024Scientific Reports9 citationsOpen Access
Differential impacts of body composition on oxygen kinetics and exercise tolerance of HFrEF and HFpEF patients
Structured PICO
Does body composition differentially impact oxygen kinetics and exercise tolerance in HFrEF compared to HFpEF patients?
P
Population
HFrEF and HFpEF patients
I
Intervention
Body composition (adiposity and lean mass)
C
Comparator
HFrEF vs HFpEF patients
O
Outcome
Oxygen kinetics and exercise tolerancesurrogate
Adverse body composition (increased adiposity, reduced lean mass) impairs oxygen diffusion and uptake kinetics specifically in HFrEF patients, highlighting peripheral mechanisms of exercise intolerance.
Abstract
delivery compared to HFpEF patients, indicating compromised peripheral function. Additionally, increased adiposity and reduced lean mass are linked to decreased oxygen diffusion capacity and impaired oxygen uptake kinetics in HFrEF patients.