Association Between Inflammation and Risk of Cardiovascular Mortality in Cancer Survivors

Figures

• 

  Figure 1. Flow Diagram of the Study Population ∗Missing variables include age, sex, ethnic, education, body mass index, waist circumference, number of times per week consuming processed meats, number of times per day consuming fruit or vegetables, smoking history, alcohol consumption, physical activity, C-reactive protein, low-density lipoprotein cholesterol, high-density lipoprotein cholesterol, triglyceride, family history of cardiovascular disease, antihypertensive medication, diabetes medication, and statin. CRP = C-reactive protein.

• 

  Figure 2. Cumulative Incidence of Cardiovascular Mortality by C-Reactive Protein Level Univariate competing-risk analyses were performed, and cumulative-incidence function curves were plotted to visualize cardiovascular death changes for cancer survivors over time. P <0.001. Abbreviation as in Figure 1.

• 

  Figure 3. Dose–Response Relationship Between C-Reactive Protein Level and Cardiovascular Mortality Restricted cubic-spline (4 knots at 5th, 35th, 65th, 95th percentiles) illustrating the multivariable-adjusted, nonlinear dose–response relationship between continuous CRP levels and HR for CV mortality; shaded area represents 95% confidence band. Reference (HR = 1.0) set at CRP = 2 mg/L. Abbreviation as in Figure 1.

• 

  Central Illustration. Association Between Inflammation and Risk of Cardiovascular Mortality in Cancer Survivors Top panel: Flow diagram of the study population, including application of inclusion/exclusion criteria and final sample size available for analysis. Middle panel: Cumulative incidence of cardiovascular mortality by C-reactive protein level, estimated with Gray’s test for competing events (cancer death) P <0.001. Bottom panel: Restricted cubic spline (4 knots at 5th, 35th, 65th, 95th percentiles) illustrating the multivariable-adjusted, nonlinear dose–response relationship between continuous C-reactive protein levels and HR for cardiovascular mortality; shaded area represents 95% confidence band. Reference (HR: 1.00) set at CRP = 2 mg/L. Abbreviation as in Figure 1.