Population
Dermal fibroblasts from a 30-year-old man with a clinical diagnosis of arrhythmogenic right ventricular…
Comparison
Generation of patient-specific induced… vs Cardiomyocytes derived from control iPSCs
Design
Preclinical
Follow-up
2 weeks
Authors
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iPSC-cardiomyocytes model ARVC adipogenic phenotype in vitro; leaves open clinical translation and requires further validation.
Patient-specific iPSC-derived cardiomyocytes can successfully model ARVC in vitro, demonstrating reduced desmosomal protein localization and an adipogenic phenotype.
Ma et al. (2012) studied this question.
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