Key result
Arrhythmogenic right ventricular cardiomyopathy is characterized by disrupted differentiation of cardiac progenitor cells to adipocytes driven by suppressed canonical Wnt signaling.
ARVC pathogenesis involves disrupted differentiation of cardiac progenitor cells due to suppressed canonical Wnt signaling, highlighting it as a disease of cardiac stem cells and offering potential for novel diagnostic and therapeutic targets.
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No immediate change to ARVC practice; leaves open Wnt modulation as a research target in cardiac progenitors.
Lombardi et al. (2010) conducted a review in Arrhythmogenic right ventricular cardiomyopathy (ARVC). Arrhythmogenic right ventricular cardiomyopathy is characterized by disrupted differentiation of cardiac progenitor cells to adipocytes driven by suppressed canonical Wnt signaling.
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