Why the study?
Does knockdown of PKP2 expression alter sodium current and action potential propagation in cultured cardiac myocytes?
Population
Cultured cardiac myocytes
Design
Preclinical
Authors
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May link PKP2 loss to sodium channel dysfunction in ARVC; leaves open therapeutic relevance pending in vivo validation.
Does knockdown of PKP2 expression alter sodium current and action potential propagation in cultured cardiac myocytes?
PKP2 interacts with Na(V)1.5, and its loss alters sodium current and conduction velocity, providing potential mechanistic insights into arrhythmogenic right ventricular cardiomyopathy.
Sato et al. (2009) studied this question.
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