What question did this study set out to answer?

Review the appropriate application, interpretation, advantages, and limitations of landmark analysis for evaluating time-to-event outcomes defined after baseline.

May 1, 2011Circulation Cardiovascular Quality and Outcomes

Landmark Analysis at the 25-Year Landmark Point

View Full Paper

Ask AI

Bookmark

Authors

UDUrania DafniNational and Kapodistrian University of Athens

Discussion

Member takes

Implication

Methodological study demonstrates unbiased time-to-event estimation in clinical follow-up cohorts, highlighting the value of landmark analysis when acknowledging conditional limitations.

Key Points

Review the appropriate application, interpretation, advantages, and limitations of landmark analysis for evaluating time-to-event outcomes defined after baseline.
Examined the historical context, methodological rationale, and alternative analytical frameworks for handling post-baseline grouping.
Performed statistical simulations utilizing realistic clinical parameters modeled on a recent cardiovascular study.
Demonstrated that landmark analysis produces unbiased estimates of time-to-event probabilities conditional on patient classification at the prespecified landmark point.
Confirmed that the methodology retains substantial analytic utility 25 years after its introduction provided its conditional nature is explicitly interpreted.

Cite This Study

Urania Dafni (2011) studied this question.

synapsesocial.com/papers/69fa8a67b07e454794a53c3e https://doi.org/10.1161/circoutcomes.110.957951

View Full Paper

Ask AI

Bookmark

Implication

Methodological study demonstrates unbiased time-to-event estimation in clinical follow-up cohorts, highlighting the value of landmark analysis when acknowledging conditional limitations.

Landmark Analysis at the 25-Year Landmark Point

Discussion

Member takes

Implication

Key Points

Cite This Study

Landmark Analysis at the 25-Year Landmark Point

Discussion

Member takes

Implication

Key Points

Cite This Study

Also Consider

Also Consider