Nano-primed reprogrammed neurons suppress the glial scar and facilitate axonal regeneration after spinal cord injury

Xuan Sun; Jiangnan Yu; Wenwen Deng; Ximing Xu

doi:10.1039/d6tb00620e

January 1, 2026Journal of Materials Chemistry B

Nano-primed reprogrammed neurons suppress the glial scar and facilitate axonal regeneration after spinal cord injury

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Key Points

To investigate how nano-primed reprogrammed neurons can influence glial scar formation and axonal regeneration following spinal cord injury.
Utilized nano-primed reprogrammed neurons in an experimental model of spinal cord injury.
Assessed glial scar formation and axonal regeneration post-treatment.
Performed chemical reprogramming to create neuron-like cells.
Demonstrated a significant reduction in glial scar formation.
Facilitated axonal regeneration after spinal cord injury was observed.

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Implication

Experimental intervention reduces glial scar formation after spinal cord injury, suggesting enhanced axonal regeneration.

Abstract

Spinal cord injury (SCI) often results in permanent sensory-motor deficits due to the formation of an inhibitory glial scar and the massive loss of neurons. Chemical reprogramming into induced neuron-like...

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Cite This Study

Sun et al. (2026) studied this question.

synapsesocial.com/papers/69fa8e0b04f884e66b5305a7 https://doi.org/10.1039/d6tb00620e

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Nano-primed reprogrammed neurons suppress the glial scar and facilitate axonal regeneration after spinal cord injury

Key Points

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

Nano-primed reprogrammed neurons suppress the glial scar and facilitate axonal regeneration after spinal cord injury

Key Points

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

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