ABSTRACT Catheter‐associated urinary tract infections (CAUTIs) are a significant complication of indwelling urinary catheters, primarily caused by bacterial adhesion, biofilm formation and catheter‐induced mechanical irritation. To reduce the risk of infection and enhance catheter safety and performance, this study developed an antibacterial lubricating coating. The coating was fabricated on a polytetrafluoroethylene (PTFE) substrate via electrostatic self‐assembly, combining dopamine‐modified hyaluronic acid–dopamine (HA–DN) as a biomimetic adhesive with aminated mesoporous silica nanoparticles (AMSN) serving as a long‐acting drug delivery carrier loaded with triclosan (TCS). The results demonstrated that the prepared AMSN exhibited a uniform particle size of approximately 80 nm, an ordered mesoporous structure and a high drug‐loading capacity, enabling sustained in vitro release of TCS for up to 144 h. Additionally, the composite multilayer coating significantly improved surface hydrophilicity and lubricity, exhibited strong antibacterial activity against Escherichia coli and Staphylococcus aureus and maintained good biocompatibility. These findings highlight its potential for preventing CAUTIs and enhancing the safety of indwelling urinary catheters.
Hu et al. (Thu,) studied this question.
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