Case report suggests FDG PET/CT detects lung metastases in succinate dehydrogenase-deficient renal carcinoma, indicating its potential role in management.
Succinate dehydrogenase-deficient renal cell carcinoma is a rare and recently recognized distinct subtype of renal cell carcinoma. Usefulness of FDG PET/CT in the management of this tumor is rarely reported. We describe FDG PET/CT findings in a case of succinate dehydrogenase-deficient renal cell carcinoma with lung metastases. The lung metastases <2 cm showed high FDG uptake with SUVmax of 19.1, which may be due to extreme Warburg effect resulting from succinate dehydrogenase mutation. This case indicates FDG PET/CT may be useful for detecting and staging of this novel tumor, which needs to be investigated in future studies.
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Zhang et al. (2026) studied this question.
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