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May 6, 2026Circulation

Abstract WE465: Pharmacologic Treatment To Lower Blood Pressure In Hypertensive Pregnant Women Living In Low- And Middle-Income Countries: Systematic Review

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Authors

OOOlufemi OlatidoyeZTZarrin TasnimJUJohn Usseglio

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Overview

Systematic review shows no consistent blood pressure reduction in antihypertensive drugs among hypertensive women in LMICs, highlighting maternal mortality risk.

Key Points

  • To evaluate pharmacologic treatment options for lowering blood pressure in hypertensive pregnant women in low- and middle-income countries.
  • Conducted systematic literature search across multiple databases
  • Included 11 trials with a total of 2118 pregnant females
  • Primary outcome was the difference in mean arterial pressure between treatment arms
  • Compared antihypertensive drugs like nifedipine and labetalol to others
  • Identified 11 trials, showing no consistent difference in blood pressure-lowering efficacy among studied drugs.
  • Blood pressure difference ranged from 0.07 to 5.7 mmHg among trials.
  • Oral nifedipine and labetalol had fewer side effects compared to hydralazine and methyldopa.

Cite This Study

Olatidoye et al. (2026) studied this question.

synapsesocial.com/papers/69fa8eac04f884e66b5310cahttps://doi.org/10.1161/cir.153.suppl_1.we465
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Oral antihypertensive therapy for severe hypertension in pregnancy and postpartum: a systematic review2014 · 105 citations
  2. 2Oral antihypertensive regimens (nifedipine retard, labetalol, and methyldopa) for management of severe hypertension in pregnancy: an open-label, randomised controlled trial2019 · 181 citations
  3. 3Antihypertensive Medications for Severe Hypertension in Pregnancy: A Systematic Review and Meta-Analysis2022 · 44 citations
  4. 4Antihypertensive Choices during Pregnancy in Limited Setting2023 · 4 citations
  5. 5Treatment for mild hypertension in pregnancy with different strategies: A systematic review and meta‐analysis2022 · 13 citations