Why the study?
Antihypertensive agents used during pregnancy vary by institution and resource availability, warranting evaluation of drug profiles and their impact on maternal and fetal outcomes in low-middle-income countries.
What are the commonly used antihypertensive drugs and their safety profiles in hypertensive pregnant women in a limited resource setting?
What are the commonly used antihypertensive drugs and their safety profiles in hypertensive pregnant women in a limited resource setting?
In a limited-resource setting, the combination of nifedipine and methyldopa is the most common and safe antihypertensive choice for hypertensive pregnant women, effectively lowering blood pressure without causing hypotension.
Answers are grounded in this paper and cite their sources.
May support nifedipine-methyldopa for BP control in limited-resource pregnancy hypertension; leaves open prospective outcome comparisons.
Abstract : Antihypertensive agents used during pregnancy may vary from institution to institution and depend on resource availability. Objective: This study aimed to determine the profile of antihypertensive drugs used in pregnancy in low-middle-income countries and the impact of these drugs on maternal and fetal outcomes. Materials and Methods: This is a retrospective study on hypertensive pregnant patients admitted to the emergency unit at a tertiary referral Hospital in Indonesia. The type of hypertension during pregnancy, antihypertensive drugs, side effect, and maternal and perinatal outcomes was extracted from medical hospital records. Results: A total of 762 hypertensive pregnant women were recruited; 61 were diagnosed with preeclampsia, 491 were preeclampsia with severe features and 174 were chronic hypertension superimposed preeclampsia, and 81.54% of them received antihypertension therapy. The most commonly prescribed antihypertensive drugs were combination therapy of nifedipine and methyldopa (96.7%), followed by monotherapy of methyldopa (2.3%), nicardipine (1.1%), and nifedipine (0.2%). Most of the patients successfully attained a Systolic blood pressure<160mmHg. Tachycardia was reported in 47 (7.9%) pregnant women who received antihypertensive medication; none reported hypotension and arrhythmia. Conclusion: Nifedipine and methyldopa are choices for an antihypertensive agent in limited resources, either monotherapy or combined. Nifedipine's immediate release can be used with a low risk of hypotension.
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Ernawati et al. (2023) studied this question.
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