What question did this study set out to answer?

This research aims to explore the effects of Fh15 on gut microbiota during colitis.

May 6, 2026International Journal of Molecular SciencesOpen Access

Intermittent Administration of Helminth-Derived Fh15 Modulates Gut Microbiota and Partially Mitigates Dysbiosis in Early Stages of Severe Experimental Colitis

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Authors

MFMaría Del Mar Figueroa-GispertUniversity of Puerto Rico, Medical Sciences Campus NMNatalie M. Meléndez-VázquezUniversity of Puerto Rico, Medical Sciences Campus AEAna M. EspinoUniversity of Puerto Rico, Medical Sciences Campus

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Implication

Intermittent Fh15 administration shows partial restoration of gut microbiota diversity in ulcerative colitis, suggesting its anti-inflammatory potential.

Key Points

This research aims to explore the effects of Fh15 on gut microbiota during colitis.
C57BL/6 mice were treated with 4% DSS to induce colitis for 7 days,
Fh15 (2 mg/kg) was administered intraperitoneally on days 1, 3, and 5,
Fecal samples were collected on days 2, 4, and 7 for 16S rRNA gene sequencing,
Standard microbiota pipelines evaluated community diversity.
DSS treatment resulted in disrupted gut microbial diversity and community structure,
Fh15 treatment partially restored microbial balance towards that of healthy mice,
Microbial dispersion was reduced, indicating enhanced community stability despite dysbiosis.
Fh15 mitigated the expansion of pro-inflammatory genera like Enterococcus and Turicibacter.

Cite This Study

Figueroa-Gispert et al. (2026) studied this question.

synapsesocial.com/papers/69fa8eac04f884e66b5310ef https://doi.org/10.3390/ijms27094068

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Implication

Intermittent Fh15 administration shows partial restoration of gut microbiota diversity in ulcerative colitis, suggesting its anti-inflammatory potential.

Intermittent Administration of Helminth-Derived Fh15 Modulates Gut Microbiota and Partially Mitigates Dysbiosis in Early Stages of Severe Experimental Colitis

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Implication

Key Points

Cite This Study

Intermittent Administration of Helminth-Derived Fh15 Modulates Gut Microbiota and Partially Mitigates Dysbiosis in Early Stages of Severe Experimental Colitis

Discussion

Member takes

Implication

Key Points

Cite This Study

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