What question did this study set out to answer?

This research aims to identify sex differences in proteins associated with incident ischemic stroke.

May 6, 2026Circulation

Abstract WE564: Identifying Sex Differences in Proteins Associated with Incident Ischemic Stroke in the UK Biobank

Q: What are the key findings of this study?

Sex-specific proteomic scores were significantly associated with incident ischemic stroke, yielding odds ratios per 1 SD increase of 1.42 (95% CI 1.18-1.70) in men and 1.58 (95% CI 1.30-1.93) in women.

Q: What is the clinical evidence from this study?

Study design: Case-Control. Population: Ischemic Stroke (n=52292). Intervention: Sex-specific proteomic scores vs. Lower proteomic score (per 1 SD decrease). Primary outcome: Incident ischemic stroke (OR 1.42 (men), OR 1.58 (women), 95% CI 1.18-1.70 (men), 1.30-1.93 (women), p=<0.05).

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Key result

Sex-specific proteomic scores are linked to ~40-60% higher ischemic stroke risk per SD.

OR 1.42 (men), OR 1.58 (women)
95% CI 1.18-1.70 (men), 1.30-1.93 (women)
P<0.05
n=52,292

Why the study?

Are there sex differences in proteomic signatures associated with incident ischemic stroke?

Population

52,292 participants from the UK Biobank, including 609 men and 445 women who developed incident ischemic…

Comparison

Measurement of 2,911 proteins using the OLINK… vs Age-matched controls without incident ischemic…

Design

Case-control

Follow-up

Median 8.6 years in men and 9.1 years in women

Authors

BABenjamin AbijahUniversity of Massachusetts Amherst KSKevin SanchezBrigham and Women's Hospital MJMargaret JaniczekAmherst College

Discussion

Member takes

Implication

Proteomic profiling identified sex-specific protein signatures associated with incident ischemic stroke, highlighting potential differences in underlying pathophysiology between men and women.

Key Points

This research aims to identify sex differences in proteins associated with incident ischemic stroke.
Analyzed protein levels in 24,041 men and 28,251 women from the UK Biobank using the OLINK platform.
Matched ischemic stroke cases (609 men, 445 women) with 20 age-matched controls each.
Assessed protein associations with stroke using conditional logistic regression, adjusted for various factors.
Derived sex-specific ischemic stroke scores through LASSO logistic regression.
148 proteins were identified as associated with ischemic stroke in men, women, or both.
No significant protein-sex interactions found, but 9 proteins showed suggestive interactions.
Cerebellin-4 inversely associated with stroke risk in women but not in men, with several proteins positively linked to stroke risk in women.

Study Design

Type

Case-Control (n=52,292)

Structured PICO

Are there sex differences in proteomic signatures associated with incident ischemic stroke?

Population

52,292 participants from the UK Biobank (54% female), including 1,054 incident ischemic stroke cases matched to 21,080 controls, followed for a median of ~9 years.

Exposure

Measurement of 2,911 proteins using the OLINK platform to derive sex-specific ischemic stroke scores.

Comparator

Age-matched controls without incident ischemic stroke.

Outcome

Incident ischemic stroke.hard clinical

Main Result

Effect estimate: OR 1.42 (men), OR 1.58 (women) (95% CI 1.18-1.70 (men), 1.30-1.93 (women))

p-value: p=<0.05

Proteomic profiling identified sex-specific protein signatures associated with incident ischemic stroke, highlighting potential differences in underlying pathophysiology between men and women.

Cite This Study

Abijah et al. (2026) conducted a case-control in Ischemic Stroke (n=52,292). Sex-specific proteomic scores vs. Lower proteomic score (per 1 SD decrease) was evaluated on Incident ischemic stroke (OR 1.42 (men), OR 1.58 (women), 95% CI 1.18-1.70 (men), 1.30-1.93 (women), p=<0.05). Sex-specific proteomic scores were significantly associated with incident ischemic stroke, yielding odds ratios per 1 SD increase of 1.42 (95% CI 1.18-1.70) in men and 1.58 (95% CI 1.30-1.93) in women.

synapsesocial.com/papers/69fa8ef304f884e66b53156a https://doi.org/10.1161/cir.153.suppl_1.we564

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Implication

Proteomic profiling identified sex-specific protein signatures associated with incident ischemic stroke, highlighting potential differences in underlying pathophysiology between men and women.

Abstract WE564: Identifying Sex Differences in Proteins Associated with Incident Ischemic Stroke in the UK Biobank

Discussion

Member takes

Implication

Key Points

Study Design

Structured PICO

Main Result

Cite This Study

Abstract WE564: Identifying Sex Differences in Proteins Associated with Incident Ischemic Stroke in the UK Biobank

Discussion

Member takes

Implication

Key Points

Study Design

Structured PICO

Main Result

Cite This Study

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