Active-Template CuAAC Enables High-Yield Synthesis of (2)Handcuff [2]Rotaxanes

Arjun Prakash; Helal Metawi; Abed Saady

doi:10.1039/d5cc07117h

January 1, 2026Chemical Communications

Active-Template CuAAC Enables High-Yield Synthesis of (2)Handcuff [2]Rotaxanes

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Key Points

To explore an active-template strategy for synthesizing (2)handcuff [2]rotaxanes efficiently.
Utilized an active-template CuAAC strategy for synthesis.
Employed a bis-2,2′-bipyridine macrocycle as a CuI ligand.
Conducted dual CuAAC reactions to create rotaxanes.
Achieved high isolated yields in the synthesis of (2)handcuff [2]rotaxanes.
Demonstrated the effectiveness of the bis-2,2′-bipyridine ligand in templating.

Implication

Active-template CuAAC achieves high synthesis yields of handcuff rotaxanes using a bis-2,2′-bipyridine ligand.

Abstract

An active-template CuAAC strategy enables the efficient synthesis of (2)handcuff [2]rotaxanes in high isolated yields. A bis-2,2′-bipyridine macrocycle acts as a CuI ligand that templates dual CuAAC reactions and enforces...

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Cite This Study

Prakash et al. (2026) studied this question.

synapsesocial.com/papers/69fa8ef304f884e66b531627 https://doi.org/10.1039/d5cc07117h

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Active-Template CuAAC Enables High-Yield Synthesis of (2)Handcuff [2]Rotaxanes

Key Points

Implication

Abstract

Discussion

Cite This Study

Active-Template CuAAC Enables High-Yield Synthesis of (2)Handcuff [2]Rotaxanes

Key Points

Implication

Abstract

Discussion

Cite This Study

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