Active-Template CuAAC Enables High-Yield Synthesis of (2)Handcuff 2Rotaxanes

Key Points

• To explore an active-template strategy for synthesizing (2)handcuff [2]rotaxanes efficiently.
• Utilized an active-template CuAAC strategy for synthesis.
• Employed a bis-2,2′-bipyridine macrocycle as a CuI ligand.
• Conducted dual CuAAC reactions to create rotaxanes.
• Achieved high isolated yields in the synthesis of (2)handcuff [2]rotaxanes.
• Demonstrated the effectiveness of the bis-2,2′-bipyridine ligand in templating.