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May 6, 2026MicrobiologyOpenOpen Access

Phage Therapy as an Alternative Strategy Against Pseudomonas aeruginosa : A Narrative Review of Preclinical and Clinical Evidence

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Authors

GCGustavo Aparecido da CunhaRARaíne Piva AmaralDSdos Santos

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Overview

Narrative review demonstrates phage therapy's potential against multidrug-resistant Pseudomonas aeruginosa infections in chronic wounds and cystic fibrosis patients, highlighting regulatory challenges

Key Points

  • To evaluate the potential effectiveness of phage therapy against Pseudomonas aeruginosa infections.
  • Narrative review of literature from PubMed/Medline, Scopus, and Web of Science.
  • Evaluation of phage administration effects in managing Pseudomonas aeruginosa infections in animal and human studies.
  • Analysis of interventions' characteristics and bacterial strain coverage.
  • Phage therapy is safe and effective for treating infections caused by multidrug-resistant and extensively drug-resistant strains.
  • Challenges include lack of standardized dosing and regulatory frameworks for clinical practice.
  • Future studies should focus on regulatory validation and standardization of phage production.

Cite This Study

Cunha et al. (2026) studied this question.

synapsesocial.com/papers/69fa979b04f884e66b531709https://doi.org/10.1002/mbo3.70303
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Bridging the gap between experimental evidence and clinical applications of antipseudomonal phage therapy against Pseudomonas aeruginosa2026
  2. 2Bacteriophage therapy in clinical practice: case studies of 2025 · 6 citations
  3. 3A novel isolated phage targeting Pseudomonas aeruginosa demonstrates therapeutic potential2026
  4. 4A Novel Bacteriophage Infecting Multi-Drug- and Extended-Drug-Resistant Pseudomonas aeruginosa Strains2024 · 10 citations
  5. 5Advances in Bacteriophage Therapy against Relevant MultiDrug-Resistant Pathogens2021 · 86 citations