Abstract WE565: Association of Stroke Subtypes With Sociodemographic, Modifiable, and Nonmodifiable Risk Factors in an Adult Asian Population: A Cross-Sectional Study

Introduction: Stroke incidence in Asia has nearly doubled over the past three decades, driven by demographic aging and lifestyle transitions. Yet, few studies have simultaneously examined how sociodemographic, modifiable, and nonmodifiable factors influence specific stroke subtypes. This study aimed to identify determinants associated with transient ischemic attack (TIA), ischemic stroke, and hemorrhagic stroke in an adult Asian cohort to inform population-specific prevention strategies. Methods: A hospital-based cross-sectional study was conducted among 238 adults with confirmed stroke at tertiary centers in Western India. Participants were categorized into TIA, ischemic, and hemorrhagic subtypes. Sociodemographic data and clinical risk factors were collected through structured interviews. Associations between variables and stroke subtypes were assessed using chi-square tests, with significance defined as p < 0.05. Results: Of 238 participants, 62.2% were male and 71.4% were aged > 60 years. Ischemic stroke was significantly associated with male sex, older age, and rural residence (all p < 0.05). Modifiable factors linked to ischemic stroke included obesity, tobacco use, dyslipidemia, and diabetes mellitus (p < 0.05 for each), while hypertension showed a stronger association with hemorrhagic stroke (p < 0.01). Among nonmodifiable variables, age > 70 years, positive family history, prior stroke, and ischemic heart disease were each significantly related to ischemic stroke (all p < 0.05). Conclusions: Distinct demographic and clinical profiles characterize stroke subtypes in Asian populations. Metabolic and lifestyle factors predominated in ischemic stroke, whereas hypertension remained the principal determinant of hemorrhagic events. These findings highlight the need for integrated, community-based screening and targeted modification of behavioral and metabolic risks to curb the growing stroke burden across low- and middle-income countries.