In vitro analysis shows Tetragonia tetragonoides reduces inflammatory responses in keratinocytes, suggesting its potential as an anti-inflammatory agent.
) was identified as the predominant compound in TTL. In TNF-α/IFN-γ-stimulated HaCaT keratinocytes, the TTL extract exhibited no cytotoxicity and significantly attenuated inflammatory responses, as evidenced by reduced secretion of pro-inflammatory chemokines, including IL-8 and MCP-1. Gene expression analysis further demonstrated that TTL extract broadly suppressed inflammation-related mediators involved in AD pathogenesis. These findings suggest that TTL extract represents a promising natural anti-inflammatory agent with potential applicability in the management of AD.
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Lee et al. (2026) studied this question.
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