Dietary N-acylethanolamines are bioaccessible in the small intestine and modulate postprandial hormonal responses: a randomized crossover trial in subjects with ileostomy

Silvia Tagliamonte; Holly Neill; Brian Murphy; L. Kirsty Pourshahidi; Francesca De Filippis; Danilo Ercolini; Chris Gill; Natália Koós; Brendan Curran; Nicole Murray; Mary Slevin; Sara Dobani; Massimiliano Fontana; Paola Vitaglione

doi:10.1039/d5fo03328d

January 1, 2026Food & FunctionOpen Access

Dietary N-acylethanolamines are bioaccessible in the small intestine and modulate postprandial hormonal responses: a randomized crossover trial in subjects with ileostomy

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Key Points

This research aims to explore how dietary n-acylethanolamines affect hormonal responses in individuals with ileostomy.
Study design
Participants included subjects with ileostomy
Effects on hormonal responses analyzed after dietary consumption of n-acylethanolamines
Dietary n-acylethanolamines significantly modulated hormonal responses postprandially
Inflammation markers were assessed alongside hormonal levels

Implication

Shows dietary n-acylethanolamines modulate hormonal responses in ileostomy patients, indicating potential appetite regulation benefits.

Abstract

N-acylethanolamines (NAEs) are bioactive lipid mediators involved in the regulation of appetite, inflammation, and gut-brain signaling. This study investigated the metabolic fate of dietary NAEs following the consumption of two...

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Cite This Study

Tagliamonte et al. (2026) studied this question.

synapsesocial.com/papers/69fa97ce04f884e66b5319da https://doi.org/10.1039/d5fo03328d

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Dietary N-acylethanolamines are bioaccessible in the small intestine and modulate postprandial hormonal responses: a randomized crossover trial in subjects with ileostomy

Key Points

Implication

Abstract

Discussion

Cite This Study

Dietary N-acylethanolamines are bioaccessible in the small intestine and modulate postprandial hormonal responses: a randomized crossover trial in subjects with ileostomy

Key Points

Implication

Abstract

Discussion

Cite This Study

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