What type of study is this?

This is a Photoaffinity Labeling study.

September 10, 2025Journal of the American Chemical Society

Photoaffinity Labeling Reveals a Role for the Unusual Triply Acylated Phospholipid N-Acylphosphatidylethanolamine in Lactate Homeostasis

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Authors

DCDin-Chi Chiu YCYuan‐Ting Cho HLHening Lin

Discussion

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Overview

Photoaffinity labeling uncovers N-acylphosphatidylethanolamine's influence on lactate transport mechanisms, suggesting new metabolic roles in ischemia.

Key Points

N-acylphosphatidylethanolamine stimulates lactate efflux, highlighting its role in energy homeostasis during ischemia.
Analysis identified interactions between N-acylphosphatidylethanolamine and key membrane proteins CD147 and CD44, essential for lactate transport.
Photoaffinity labeling was employed to discern specific protein interactions with N-acylphosphatidylethanolamine without interference from N-acylethanolamine.
These findings indicate that N-acylphosphatidylethanolamine could have significant physiological roles relevant to metabolic stress conditions.

Cite This Study

Chiu et al. (2025) studied this question.

synapsesocial.com/papers/68c1925e9b7b07f3a0616ff3 https://doi.org/10.1021/jacs.5c03851

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September 10, 2025Journal of the American Chemical Society

Photoaffinity Labeling Reveals a Role for the Unusual Triply Acylated Phospholipid N-Acylphosphatidylethanolamine in Lactate Homeostasis

View Full Paper

Ask AI

Bookmark

Authors

DCDin-Chi Chiu YCYuan‐Ting Cho HLHening Lin

Discussion

Member takes

Overview

Photoaffinity labeling uncovers N-acylphosphatidylethanolamine's influence on lactate transport mechanisms, suggesting new metabolic roles in ischemia.

Key Points

N-acylphosphatidylethanolamine stimulates lactate efflux, highlighting its role in energy homeostasis during ischemia.
Analysis identified interactions between N-acylphosphatidylethanolamine and key membrane proteins CD147 and CD44, essential for lactate transport.
Photoaffinity labeling was employed to discern specific protein interactions with N-acylphosphatidylethanolamine without interference from N-acylethanolamine.
These findings indicate that N-acylphosphatidylethanolamine could have significant physiological roles relevant to metabolic stress conditions.

Cite This Study

Chiu et al. (2025) studied this question.

synapsesocial.com/papers/68c1925e9b7b07f3a0616ff3 https://doi.org/10.1021/jacs.5c03851

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