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August 16, 2026ChemBioChemOpen Access

Metabolic Labeling of Phosphatidylethanolamine Lipids in Cells Using Clickable Ethanolamine Analogs

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Authors

RMRobert J. MaraskiJLJinchao LouUniversity of MississippiTRTodd B. ReynoldsUniversity of Tennessee at Knoxville

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Implication

In vitro experimental study demonstrates metabolic labeling and visualization of phosphatidylethanolamine lipids in mammalian cells, highlighting a new strategy to track lipid trafficking.

Key Points

  • To develop functionalized, clickable ethanolamine probes capable of infiltrating native biosynthetic pathways to metabolically label and image phosphatidylethanolamine lipids in cells.
  • Synthesized clickable ethanolamine analogs designed to integrate into endogenous lipid biosynthesis pathways.
  • Identified and verified probe incorporation into phosphatidylethanolamine species using mass spectrometry and thin-layer chromatography.
  • Visualized labeled intracellular lipids through bioorthogonal click-reaction derivatization and fluorescence microscopy.
  • Clickable ethanolamine analogs effectively infiltrated cellular pathways to generate tagged phosphatidylethanolamine lipid species.
  • Bioorthogonal derivatization of tagged lipids enabled direct fluorescence microscopy imaging of phosphatidylethanolamine distribution within cells.

Cite This Study

Maraski et al. (2026) studied this question.

synapsesocial.com/papers/6a817a11f2fb91fc834adae5https://doi.org/10.1002/cbic.70501
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