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This research aims to explore the antibacterial potential of light-controlled amphiphilic lipids against gram-positive bacteria.

May 6, 2026RSC Medicinal Chemistry0 citationsOpen Access

Light-Controlled Inhibition of Gram-Positive Bacteria by Photoswitchable Amphiphilic Lipids (PALs)

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GFGuilherme FernandesUniversity College London SKSeong Heun KimKing's College London CHCharlotte K. HindDefence Science and Technology Laboratory

Key Points

This research aims to explore the antibacterial potential of light-controlled amphiphilic lipids against gram-positive bacteria.
Development of photoswitchable amphiphilic lipids (PALs)
Testing of PALs against various strains of gram-positive bacteria
Assessment of the modulation of antibacterial potency through light exposure.
Successful light-controlled inhibition of gram-positive bacteria
Ability to reverse antibacterial potency through light modulation
Demonstration of enhanced efficacy compared to traditional amphiphilic lipids.

Abstract

Amphiphilic lipids are potent membrane-disrupting antibacterials, but their activity cannot normally be modulated after administration. Here we report photoswitchable amphiphilic lipids (PALs) that enable reversible, light-controlled modulation of antibacterial potency...

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Light-Controlled Inhibition of Gram-Positive Bacteria by Photoswitchable Amphiphilic Lipids (PALs)

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