PulseExploreJournal ClubDebatesTrendingResearchersJournals
Instagram
HomeExploreJournal ClubTrending
Synapse
⌘+K
Synapse
May 6, 2026Biomedicines0 citationsOpen Access

Understanding Malignant Transformation in Lower-Grade Gliomas and Implications for Treatment

From Epigenetic Constraint to Evolutionary Escape: Cell-State Transitions and Selective Pressures During Malignant Transformation in Lower-Grade Gliomas

View Full Paper
Ask AI
Bookmark
Share

Authors

HWHao WuYWYi WeiXZXing-Ding Zhang

Discussion

Loading...

Member takes

Overview

Review uncovers mechanisms of malignant transformation in lower-grade gliomas, indicating involvement of epigenetic factors and genomic instability.

Key Points

  • To explore how lower-grade gliomas undergo malignant transformation through cell-state transitions and external pressures.
  • Review of literature on lower-grade gliomas and malignant transformation
  • Analysis of cellular states and their evolution under therapeutic and environmental pressures
  • Examination of recent longitudinal and single-cell studies
  • Malignant transformation is a continuous process shaped by epigenetic constraints and selective pressures.
  • IDH-mutant tumors initially maintain restricted states before evolving due to therapy and other factors.
  • Progression involves changes in stem-like features, invasion potential, and therapeutic resistance.

Cite This Study

Wu et al. (2026) studied this question.

synapsesocial.com/papers/69fa980604f884e66b531c6fhttps://doi.org/10.3390/biomedicines14050985
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Acquired genetic and cell-state changes in IDH-mutant glioma progression2026 · 5 citations
  2. 2Abstract B032: Integrated genomic analysis defines early and late drivers of glioma evolution and survival outcome in GBM2025
  3. 3Better than hiding: high-grade glioma cells remodel the immune microenvironment to suppress cytotoxic immunity2026
  4. 4Beyond the Tumor Mass: From Initiating Clones to Overt Isocitrate Dehydrogenase-Mutant Gliomas2026 · 1 citations
  5. 5Multi-scale signaling and tumor evolution in high-grade gliomas2024 · 59 citations