The developed hydrogel demonstrates superior hemostatic and antibacterial properties in wound healing models, indicating its potential for biomedical applications.
Uncontrolled hemorrhage and subsequent infection severely impair wound healing. This study developed a multifunctional Polyamidoamine Dendrimer/Sodium Alginate/γ-polyglutamic Acid/Amoxicillin (G3/SA/γ-PGA/AMX) hydrogel via 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride and N-hydroxysuccinimide activated amidation. The hydrogel featured a porous structure, balanced mechanical properties, excellent self-healing ability, and injectability. In SD rat liver bleeding and tail amputation models, it significantly outperformed commercial gelatin sponge, reducing blood loss to 0.09 ± 0.02 g and 0.04 ± 0.01 g respectively, with hemostatic time shortened to 0.69 ± 0.17 min and 0.62 ± 0.10 min. Sustained amoxicillin release conferred over 96% bactericidal rate against Escherichia coli and Staphylococcus aureus. It exhibited negligible hemolysis and high L929 cell viability (>90%), ensuring good biocompatibility. In C57 mice scald models, the hydrogel promoted rapid wound healing with a rate exceeding 98.91 ± 1.04% after 20 days, accelerating epidermal regeneration and dense collagen deposition. These results highlight the hydrogel's superior hemostatic and wound healing capabilities, making it a promising candidate for clinical wound management.
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Jia et al. (2026) studied this question.
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