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May 6, 2026Dalton Transactions0 citationsOpen Access

Selective Defluorination of 1,1,1,2-Tetrafluoroethane by Lithium Phosphide Reagents

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HWHodan R. WarsameCDColleen DemetriouMCMark R. Crimmin

Key Points

  • This research examines the chemical reaction of HFC-134a with lithium phosphide reagents.
  • Used lithium phosphide reagents for selective defluorophosphination.
  • Reacted 1,1,1,2-tetrafluoroethane to measure the reaction outcome.
  • Performed DFT calculations for theoretical analysis.
  • Produced diphenyl(2,2,2-trifluoroethyl)phosphane as a main product.
  • Confirmed the selective reaction at the C(sp 3 )-F bond.

Abstract

1,1,1,2-Tetrafluoroethane (HFC-134a), the most commonly used 3rd generation refrigerant, reacts with lithium phosphide reagents through selective defluorophosphination of the single C(sp 3 )-F bond to yield diphenyl(2,2,2-trifluoroethyl)phosphane. DFT calculations were used to...

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Cite This Study

Warsame et al. (2026) studied this question.

synapsesocial.com/papers/69fa980604f884e66b531d58https://doi.org/10.1039/d6dt00747c
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