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May 6, 2026MicroorganismsOpen Access

Molecular Epidemiology of the blaCTX-M Gene in Escherichia coli from a Pig Farm: Antimicrobial Resistance Profiles, Genetic Background, and Its Horizontal Transfer and Environmental Dissemination

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Authors

RJRi-Han JiangHunan Agricultural UniversityLZLiu ZDongseo UniversityBHBing HanHunan Agricultural University

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Implication

Investigation reveals multi-drug resistance in Escherichia coli from pig farms, indicating high transmission risks of β-lactamase.

Key Points

  • This research aims to assess the epidemiology, antimicrobial resistance, and transmission risks of blaCTX-M-positive Escherichia coli in pig farms.
  • Conducted antimicrobial susceptibility testing on isolated strains.
  • Performed multilocus sequence typing and resistance gene profiling.
  • Assessed genetic environment and gene transfer through transduction experiments.
  • Collected samples from manure, wastewater, drinking water, and flies.
  • Twenty-seven CTX-M-EC strains were isolated, showing 100% resistance to cefotaxime, ciprofloxacin, and tetracycline.
  • Identified four blaCTX-M subtypes, with blaCTX-M-55 being the most prevalent.
  • Detected mobile elements surrounding the blaCTX-M gene that facilitate gene transfer.
  • Resistant strains identified in environmental samples indicate potential transmission between animals and the environment.

Cite This Study

Jiang et al. (2026) studied this question.

synapsesocial.com/papers/69fa983604f884e66b53207ehttps://doi.org/10.3390/microorganisms14051007
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