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May 6, 2026AntioxidantsOpen Access

Annona muricata (Soursop) and Hematopoiesis: Ethnomedicinal Insights, Immunomodulatory Mechanisms, and Translational Challenges

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Authors

FMFatma MatanoAPAmiya Patra

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Overview

Narrative review reveals A. muricata shows potential immunomodulatory bioactivity affecting hematopoiesis, indicating gaps in human evidence.

Key Points

  • To explore the potential influence of Annona muricata on hematopoiesis through a review of ethnomedicinal and experimental evidence.
  • Narrative review synthesizing ethnomedicinal knowledge, phytochemical composition, and experimental studies.
  • Evaluation of the bioactive constituents of A. muricata, such as flavonoids and polyphenols.
  • Discussion of the indirect mechanisms of action related to hematopoietic function under stress conditions.
  • A. muricata bioactive constituents demonstrated antioxidant and anti-inflammatory properties.
  • Interventions show a potential role in preserving hematopoietic function despite oxidative stress and inflammation.
  • Current evidence relies heavily on in vitro and animal studies, lacking direct human data.

Cite This Study

Matano et al. (2026) studied this question.

synapsesocial.com/papers/69fa986a04f884e66b53230bhttps://doi.org/10.3390/antiox15050579
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