Is Denture Adhesive Advantageous or a Sign of Prosthetic Failure During the Adaptation Period? A Randomized Crossover Trial

Objectives: This study aimed to evaluate the oral health-related quality of life (QoL) of Denture adhesives for completely edentulous denture wearers. Methods: A total of 32 participants (new denture wearers) were selected from a prosthodontic clinic at three dental faculties located in different regions of Egypt. The participants were allocated into two groups ( n = 16): a conventional group without denture adhesive and an adhesive group in which adhesive was applied, following a crossover study design. Patient-reported outcomes were assessed using the Oral Health Impact Profile for Edentulous Adults (OHIP-EDENT) questionnaire at 1, 2, and 3 months after insertion of the new complete dentures. Statistical analysis was performed using a mixed-effects model, with results further validated by generalized estimating equations at a significance level of α = 0.05. Results: OHIP-EDENT showed a decrease in value in the adhesive group compared with the conventional one. As total functional limitations, physical disability (eating comfort, uncomfortable dentures), total psychological discomfort, and physical discomfort showed a statistically significant difference in lower score ( P < 0.050) for the adhesive group than the conventional group along all follow-up periods. There was no statistically significant difference between the two groups ( P > 0.050) regarding psychological disability, social disability, and handicap across all follow-up periods. Conclusion: Using denture adhesives for completely edentulous patients in the adaptation period resulted in improved QoL, and the use of denture adhesives can be regarded as a reliable treatment to maximize the quality of health benefits.