What is the clinical evidence from this study?

Study design: Observational. Population: Coronary artery disease (n=901327). Intervention: Tobacco use. Primary outcome: Age-adjusted mortality rate (AAMR) attributable to CAD and tobacco use per 100,000.

What question did this study set out to answer?

This study evaluates trends in coronary artery disease mortality due to tobacco use in U.S. adults aged 25 and older, focusing on disparities.

May 6, 2026Circulation

Abstract WE555: Trends in Mortality Due to Use of Tobacco in Coronary Artery Disease Patients Among Younger and Older Adults from 1999-2023 in the USA

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Key result

Tobacco use-attributable CAD mortality surged ~7-fold among U.S. adults from 1999 to 2023.

n=901,327

Key Points

This study evaluates trends in coronary artery disease mortality due to tobacco use in U.S. adults aged 25 and older, focusing on disparities.
Retrospective analysis using CDC WONDER data from 1999 to 2023
Calculated age-adjusted mortality rates attributable to coronary artery disease and tobacco use
Employed Joinpoint regression to assess trends and estimate annual percent changes
901,327 coronary artery disease deaths attributed to tobacco use in adults ≥25 years
Age-adjusted mortality rates increased from 2.6 to 18.8 per 100,000 from 1999 to 2023
Males showed a greater burden, with trends plateauing after 2016
Highest mortality rates were observed in older adults, peaking at 72.7 in 2021
Non-Hispanic White and Black populations experienced the highest mortality burdens

Study Design

Type

Observational (n=901,327)

Multicenter

Yes

Structured PICO

Population

901,327 U.S. adults aged 25 and older who died from coronary artery disease attributable to tobacco use between 1999 and 2023.

Outcome

Age-adjusted mortality rates (AAMRs) attributable to CAD and tobacco usehard clinical

Discussion

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Implication

CAD mortality associated with tobacco use in the US has significantly increased from 1999 to 2023, disproportionately affecting males, older adults, and non-metropolitan populations.

Cite This Study

Kumar et al. (2026) conducted an observational in Coronary artery disease (n=901,327). Tobacco use was evaluated on Age-adjusted mortality rate (AAMR) attributable to CAD and tobacco use per 100,000. Tobacco use-attributable CAD mortality in U.S. adults aged ≥25 years increased significantly from 1999 to 2023, with the national age-adjusted mortality rate rising from 2.6 to 18.8 per 100,000.

synapsesocial.com/papers/69fa989404f884e66b532614 https://doi.org/10.1161/cir.153.suppl_1.we555

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Implication

CAD mortality associated with tobacco use in the US has significantly increased from 1999 to 2023, disproportionately affecting males, older adults, and non-metropolitan populations.

Abstract WE555: Trends in Mortality Due to Use of Tobacco in Coronary Artery Disease Patients Among Younger and Older Adults from 1999-2023 in the USA

Key Points

Study Design

Structured PICO

Discussion

Implication

Cite This Study

Abstract WE555: Trends in Mortality Due to Use of Tobacco in Coronary Artery Disease Patients Among Younger and Older Adults from 1999-2023 in the USA

Key Points

Study Design

Structured PICO

Discussion

Implication

Cite This Study

Also Consider

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