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Annulation of tetrahydroisoquinolines shows promise in inhibiting inflammatory mediators in macrophages, suggesting therapeutic potential.
)-H difunctionalization of 1,2,3,4-tetrahydroisoquinolines and concurrent formation of multiple C-C and C-N bonds. The resulting polycyclic scaffolds are readily transformed into multifunctional photoluminescent materials that display aggregation-induced delayed fluorescence (AIDF) emission. Preliminary biological evaluation revealed that several derivatives potently inhibit key inflammatory mediators in lipopolysaccharide-activated macrophages, indicating their potential as promising anti-inflammatory lead candidates.
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Zheng et al. (2026) studied this question.
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