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Electrochemical cyanation generates C3-cyano indoles in various substitutions, suggesting efficient regioselectivity.
An electrochemical strategy for C3‐site selective cyanation of substituted indoles is reported. This protocol employs TMSCN as a cyano source, yielding C3‐cyano indoles in moderate to good yields. The electrochemical strategy is distinguished by its mild and oxidant‐free conditions, with good regioselectivity. A variety of protected and unprotected indoles has been successfully utilized in this methodology.
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Kumar et al. (2026) studied this question.
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