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May 6, 2026JAMA3 citations

The Conundrum of Exercise for Weight Management in the GLP-1 Receptor Agonist Era

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DLDaniel E. LiebermanDADaniel H. AslanSHSteven B. Heymsfield

Key Points

  • This perspective aims to address issues in prescribing exercise for weight management alongside GLP-1 receptor agonists.
  • Discuss challenges of exercise prescription for weight loss
  • Evaluate the role of GLP-1 receptor agonists in exercise adherence
  • Propose strategies for clinicians to enhance patient adherence
  • Identified barriers to exercise adherence in patients
  • Highlighted the impact of GLP-1 receptor agonists on weight loss
  • Recommended strategies for improving patient exercise engagement

Abstract

This Perspective describes the challenges of prescribing exercise for weight loss, with and without the use of glucagon-like peptide 1 (GLP-1) receptor agonists, and discusses strategies clinicians can use to improve adherence to exercise recommendations.

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Cite This Study

Lieberman et al. (2026) studied this question.

synapsesocial.com/papers/69faa25e04f884e66b533062https://doi.org/10.1001/jama.2026.5537
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