The effects of ankle-foot orthoses on the gait of people with multiple sclerosis: a systematic review and meta-analysis

This is a Meta-Analysis study (also classified as: Systematic Review).

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Key Points

The aim is to review and quantify the effects of ankle-foot orthoses on gait in individuals with multiple sclerosis.
Systematic review of randomized controlled trials, crossover, and before-and-after clinical trials.
Searched PubMed, Scopus, and Web of Science for relevant studies assessing AFOs on gait in PwMS.
Outcomes included temporospatial, kinematic, kinetic, functional mobility, and balance measures.
AFOs improve certain biomechanical deficits in gait for individuals with multiple sclerosis.
Dynamic AFOs may enhance 6-min walk distance compared to static designs.
Evidence regarding core gait parameter improvements is limited and heterogeneous.

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Systematic review shows gait improvements in multiple sclerosis with orthotics, indicating potential for better mobility and energy management.

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Mosharaf et al. (2026) studied this question.

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