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April 28, 2026

Tumor burden score determines survival benefit of anatomic resection in hepatocellular carcinoma: A multicenter propensity-matched study.

Shujie Pang Yang Shi Minjun Jiang Qingwang Ye Xin Yan Zhe Sun 寇兴瑞 Xiaoxiang Chen Hui SiMa Yiming Chen Yingcheng Yang Ning Yang

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Key Points

To assess the impact of tumor burden score on the survival benefit of anatomic resection in hepatocellular carcinoma.
Patients were stratified by tumor burden score (TBS) into high (>5) and low (≤5) groups.
Propensity score matching was utilized to balance confounders in the high-TBS cohort.
Recurrence-free survival (RFS) was compared between high-TBS patients who underwent anatomic resection and other interventions.
Margin width did not significantly affect recurrence-free survival (RFS).
Anatomic resection significantly improved RFS in high-TBS patients (p = 0.002) but not in low-TBS patients.
After propensity score matching, RFS benefit from anatomic resection remained significant for high-TBS cohort (p = 0.012).

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Implication

Multicenter analysis demonstrates anatomic resection improves RFS in patients with high tumor burden, suggesting TBS as a preoperative predictor.

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Cite This Study

Pang et al. (2026) studied this question.

synapsesocial.com/papers/69faa28f04f884e66b5331fc https://doi.org/10.1016/j.ejso.2026.111850

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