May 6, 2026Frontiers in Cardiovascular MedicineOpen Access

The effects of SGLT2 inhibitors on atrial fibrillation recurrence and cardiac function after catheter ablation in patients with atrial fibrillation and heart failure: a retrospective cohort study and meta-analysis

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Authors

XGXueying GaoHebei Medical University ZZZhanxin ZhangHebei Medical University KCKexin ChenHebei Medical University

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Implication

Retrospective cohort study shows SGLT2 inhibitors reduce atrial fibrillation recurrence in heart failure patients after catheter ablation, indicating potential cardiac benefits.

Key Points

This research aims to evaluate the impact of SGLT2 inhibitors on atrial fibrillation recurrence and cardiac function in heart failure patients post-ablation.
Conducted a retrospective cohort study with 168 heart failure patients undergoing catheter ablation.
Compared outcomes between SGLT2i users and non-users regarding AF recurrence and cardiac function.
Performed a meta-analysis including 13 studies with 7,954 total patients investigating SGLT2i influence.
SGLT2i group experienced significantly lower AF recurrence (13.25% vs. 25.88%, P = 0.039).
SGLT2i users had smaller left atrial diameter (37.37 mm vs. 39.25 mm, P = 0.024) and higher left ventricular ejection fraction (62.06% vs. 58.89%, P = 0.039).
Meta-analysis revealed SGLT2i reduced AF recurrence risk (RR = 0.59, P < 0.001) and all-cause mortality risk (RR = 0.66, P = 0.011).

Cite This Study

Gao et al. (2026) studied this question.

synapsesocial.com/papers/69faa2b504f884e66b533420 https://doi.org/10.3389/fcvm.2026.1827339

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Implication

Retrospective cohort study shows SGLT2 inhibitors reduce atrial fibrillation recurrence in heart failure patients after catheter ablation, indicating potential cardiac benefits.

The effects of SGLT2 inhibitors on atrial fibrillation recurrence and cardiac function after catheter ablation in patients with atrial fibrillation and heart failure: a retrospective cohort study and meta-analysis

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Key Points

Cite This Study

The effects of SGLT2 inhibitors on atrial fibrillation recurrence and cardiac function after catheter ablation in patients with atrial fibrillation and heart failure: a retrospective cohort study and meta-analysis

Discussion

Member takes

Implication

Key Points

Cite This Study

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