Why the study?
Does lowering the threshold of plasma troponin concentration to the 99th centile identify patients at higher risk of recurrent myocardial infarction or death among those with suspected acute coronary syndrome?
Does lowering the threshold of plasma troponin concentration to the 99th centile identify patients at higher risk of recurrent myocardial infarction or death among those with suspected acute coronary syndrome?
Lowering the troponin diagnostic threshold to the 99th centile identifies a high-risk cohort of patients with suspected ACS who would otherwise be missed, though it increases MI diagnoses by 47%.
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Lowering troponin threshold may identify higher-risk patients otherwise missed; leaves open whether adoption improves outcomes in suspected ACS.
Mills et al. (2012) studied this question.
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