Why the study?
Does stopping warfarin before delivery or performing a cesarean section prevent fetal hemorrhage and stillbirth in pregnant rabbits?
Population
Pregnant rabbits and their fetuses
Comparison
Warfarin (coumadin) administered during pregnancy vs Continuous administration until term vs…
Design
Preclinical
Follow-up
Until delivery
Authors
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Pre-delivery warfarin cessation or cesarean avoids fetal hemorrhage in rabbits; hypothesis-generating for human pregnancy anticoagulation.
Does stopping warfarin before delivery or performing a cesarean section prevent fetal hemorrhage and stillbirth in pregnant rabbits?
In a rabbit model, the risk of fetal hemorrhage from maternal warfarin use is primarily associated with the trauma of vaginal delivery while the fetus has a severe coagulation defect.
Hirsh et al. (1970) studied this question.
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