Why the study?
What are the maternal and fetal safety outcomes of anticoagulant therapy during pregnancy?
Population
14 pregnant patients requiring anticoagulant therapy
Design
Case_series
Follow-up
Duration of pregnancy
Authors
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Anticoagulant regimen appears tolerable in pregnancy; leaves open need for prospective trials to confirm maternal-fetal safety.
What are the maternal and fetal safety outcomes of anticoagulant therapy during pregnancy?
Anticoagulant therapy with heparin and warfarin during pregnancy appears to have a manageable safety profile, supporting a regimen of heparin in the first trimester and near term, and oral anticoagulants in between.
Hirsh et al. (1970) studied this question.
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