Key result
Low molecular weight heparin is the preferred treatment for venous thromboembolism during pregnancy, whereas warfarin is not recommended during the first trimester and perinatal period.
Why the study?
What is the safest antithrombotic therapy strategy during pregnancy for indications such as VTE and mechanical heart valves?
What is the safest antithrombotic therapy strategy during pregnancy for indications such as VTE and mechanical heart valves?
LMWH is preferred for VTE during pregnancy, while mechanical heart valves require a staged approach using UFH in the first trimester and peripartum, and warfarin during the second and early third trimesters.
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Supports LMWH preference for pregnancy VTE with early warfarin avoidance; leaves open valve-specific regimens pending prospective data.
Ageno et al. (2004) conducted a review in Pregnancy requiring antithrombotic therapy. Antithrombotic therapy (Warfarin, UFH, LMWH) was evaluated. Low molecular weight heparin is the preferred treatment for venous thromboembolism during pregnancy, whereas warfarin is not recommended during the first trimester and perinatal period.
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