February 1, 1989Annual Review of Medicine
Anticoagulants During Pregnancy
Why the study?
Does heparin reduce adverse fetal effects compared to oral anticoagulants in pregnant patients requiring anticoagulation?
Population
Pregnant patients requiring anticoagulant therapy for venous thromboembolic disease or with prosthetic heart…
Comparison
Heparin vs Oral anticoagulants
Design
Review
Authors
Discussion
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Member takes
Implication
Supports heparin preference in pregnancy to limit fetal risk; leaves open optimal regimens for prosthetic valves.
Structured PICO
Does heparin reduce adverse fetal effects compared to oral anticoagulants in pregnant patients requiring anticoagulation?
P
Population
Pregnant patients requiring anticoagulant therapy for venous thromboembolic disease or with prosthetic heart valves
I
Intervention
Heparin (adjusted-dose or in combination with oral anticoagulants)
C
Comparator
Oral anticoagulants
O
Outcome
Adverse maternal and fetal effects, and efficacy in preventing systemic embolismsafety
Heparin is the preferred anticoagulant during pregnancy due to its established fetal safety profile compared to oral anticoagulants, with specific dosing strategies required for patients with prosthetic heart valves.
Cite This Study
Ginsberg et al. (1989) studied this question.