November 7, 2008Clinical ChemistryOpen Access

Short- and Long-Term Biological Variation in Cardiac Troponin I Measured with a High-Sensitivity Assay: Implications for Clinical Practice

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Structured PICO

Population

12 healthy volunteers for short-term assessment and 17 healthy individuals for long-term assessment

Intervention

Serial measurement of cardiac troponin I (cTnI) using a high-sensitivity assay (detection limit, 0.2 ng/L)

Outcome

Biological variation of cTnI including analytical, intraindividual, interindividual, and total CVs, index of individuality (II), and reference change values (RCVs)surrogate

The low index of individuality for high-sensitivity cardiac troponin I indicates that tracking serial changes in individual patients is more useful than using population-based reference intervals.

Discussion

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Implication

May favor serial hs-cTnI monitoring over population references; leaves open outcome impact in practice.

Cite This Study

Wu et al. (2008) studied this question.

synapsesocial.com/papers/69fab3d679c9fe70ce3f568b https://doi.org/10.1373/clinchem.2008.107391

View Full Paper

Ask AI

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Short- and Long-Term Biological Variation in Cardiac Troponin I Measured with a High-Sensitivity Assay: Implications for Clinical Practice

Structured PICO

Discussion

Implication

Cite This Study

Short- and Long-Term Biological Variation in Cardiac Troponin I Measured with a High-Sensitivity Assay: Implications for Clinical Practice

Structured PICO

Discussion

Implication

Cite This Study

Also Consider

Also Consider