July 26, 2004Clinical Chemistry

Serum 99th Percentile Reference Cutoffs for Seven Cardiac Troponin Assays

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Population

403 healthy volunteers with no past or current history of heart disease, median age 49, 53% female, 42%…

Design

Cross-sectional

Authors

MMMaryAnn M. MurakamiUniversity of Minnesota

Discussion

Member takes

Implication

Assay-specific cTnI thresholds required for interpretation; cross-sectional data leaves open prospective validation of gender and ethnic adjustments.

Structured PICO

Population

403 healthy volunteers with no past or current history of heart disease, median age 49 (range 30-84), 53% female, 42% African American, 45% Caucasian.

Intervention

Measurement of serum cardiac troponin using seven FDA-cleared assays (six cTnI, one cTnT)

Outcome

99th percentile reference limits for cardiac troponin concentrationssurrogate

Serum 99th percentile reference limits for cardiac troponin vary widely depending on the assay used, highlighting the need for assay-specific cutoffs and consideration of gender and ethnic differences.

Limitations

matched serum and plasma samples were not available for analysis

Cite This Study

MaryAnn M. Murakami (2004) studied this question.

synapsesocial.com/papers/6a800a905eb4cdfc7531b123 https://doi.org/10.1373/clinchem.2004.036129

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Implication

Assay-specific cTnI thresholds required for interpretation; cross-sectional data leaves open prospective validation of gender and ethnic adjustments.

Serum 99th Percentile Reference Cutoffs for Seven Cardiac Troponin Assays

Discussion

Member takes

Implication

Structured PICO

Limitations

Cite This Study

Serum 99th Percentile Reference Cutoffs for Seven Cardiac Troponin Assays

Discussion

Member takes

Implication

Structured PICO

Limitations

Cite This Study

Also Consider

Also Consider