Key result
The 99th percentile upper reference limit for Troponin I using the Bayer ACS:Centaur assay was 0.16 μg/L for both serum and heparin-plasma specimens in a healthy population.
Why the study?
What is the 99th percentile reference limit for Troponin I using the Bayer ACS:Centaur assay in a healthy population, and does specimen type (serum vs. heparin-plasma) affect the results?
Population
221 apparently healthy, asymptomatic hospital staff members, 66% female, 25-65 years of age, 92% Caucasian.
Comparison
Troponin I measurement using the Bayer… vs Comparison between serum and heparin-plasma…
Design
Cross-sectional
Authors
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May guide assay-specific troponin interpretation; leaves open validation in diverse populations before routine use.
Cross-Sectional (n=221)
Yes
What is the 99th percentile reference limit for Troponin I using the Bayer ACS:Centaur assay in a healthy population, and does specimen type (serum vs. heparin-plasma) affect the results?
Mean Difference: -0.01
Absolute Event Rate: 0.01% vs 0.02%
p-value: p=<0.001
The 99th percentile upper reference limit for Troponin I using the Bayer ACS:Centaur assay in a healthy population is 0.16 μg/L, with no clinically meaningful difference between serum and heparin-plasma specimens.
Armstrong et al. (2002) conducted a cross-sectional in Healthy, asymptomatic population (n=221). Heparin-plasma specimens vs. Serum specimens was evaluated on Mean Troponin I concentration (MD -0.01 μg/L, p=<0.001). The 99th percentile upper reference limit for Troponin I using the Bayer ACS:Centaur assay was 0.16 μg/L for both serum and heparin-plasma specimens in a healthy population.
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