Design, synthesis, biological evaluation, and molecular dynamics study of asymmetric N -isopropyl-4-piperidone diarylpentanoids as potential anticancer and anti-inflammatory agents | Synapse
May 6, 2026Open Access
Design, synthesis, biological evaluation, and molecular dynamics study of asymmetric N -isopropyl-4-piperidone diarylpentanoids as potential anticancer and anti-inflammatory agents
Key Points
This research aims to design and evaluate asymmetric N-isopropyl-4-piperidone diarylpentanoids for their anticancer and anti-inflammatory properties.
Synthesis of asymmetric N-isopropyl-4-piperidone diarylpentanoids
Biological evaluation of their anticancer and anti-inflammatory effects
Molecular dynamics simulations to assess stability and interactions
Certain diarylpentanoids exhibited significant anticancer activity in vitro.
Anti-inflammatory effects were noted, indicating potential therapeutic benefits.
Molecular dynamics highlighted favorable stability profiles for selected compounds.
Abstract
-isopropyl-4-piperidone diarylpentanoids represent promising structural frameworks for the further development of anticancer and anti-inflammatory agents.