Ln 3 TCAS 2 -polyethyleneimine supramolecular nanogels: A platform for neutron capture therapy and complementary magnetic resonance imaging (Ln = lanthanide, TCAS = thiacalix4arene- p -tetrasulfonate)

Key Points

• This research aims to develop a platform for neutron capture therapy using supramolecular nanogels.
• Prepared nanogels via electrostatic crosslinking of cationic polyethyleneimine with hepta-anionic lanthanide complexes.
• Incorporated lanthanide complexes for enhanced imaging capabilities.
• Assessed drug-loading capacity and therapeutic potential.
• Demonstrated high drug-loading capacity of the supramolecular nanogels.
• Achieved effective delivery for neutron capture therapy.
• Provided complementary capabilities for magnetic resonance imaging.