What question did this study set out to answer?

To evaluate how dense phylogenetic sampling of avian genomes improves comparative genomics, identification of orthologous regions, and detection of evolutionary selection.

November 11, 2020NatureOpen Access

Dense sampling of bird diversity increases power of comparative genomics

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Authors

SFShaohong FengSir Run Run Shaw Hospital JSJosefin StillerUniversity of Copenhagen YDYuan DengKunming University of Science and Technology

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Implication

Comparative genomic analysis reveals extensive evolutionary conservation across 363 bird species representing 92.4% of avian families, highlighting the power of dense phylogenetic sampling.

Key Points

To evaluate how dense phylogenetic sampling of avian genomes improves comparative genomics, identification of orthologous regions, and detection of evolutionary selection.
Analyzed 363 avian genomes spanning 92.4% of bird families, including 267 newly sequenced genomes from phase II of the Bird 10,000 Genomes (B10K) Project.
Implemented a reference-free whole-genome alignment pipeline to identify orthologous sequences and lineage-specific genomic novelties.
More than doubled the proportion of genomic base pairs confidently identified as undergoing evolutionary conservation.
Generated a single-base-pair map of natural selection, identifying widespread patterns of weak selection localized primarily within non-coding DNA.

Cite This Study

Feng et al. (2020) studied this question.

synapsesocial.com/papers/69fb91e5b5ea8fa7c5dfa5f3 https://doi.org/10.1038/s41586-020-2873-9

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Implication

Comparative genomic analysis reveals extensive evolutionary conservation across 363 bird species representing 92.4% of avian families, highlighting the power of dense phylogenetic sampling.

Dense sampling of bird diversity increases power of comparative genomics

Discussion

Member takes

Implication

Key Points

Cite This Study

Dense sampling of bird diversity increases power of comparative genomics

Discussion

Member takes

Implication

Key Points

Cite This Study

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