Key result
Algorithms define statin intolerance and guide clinical strategies to optimize cardiovascular risk reduction.
Why the study?
Many patients taking statins report muscle-related symptoms that prevent use of guideline recommended doses, creating a need for strategies to optimize LDL-C lowering in these patients.
This review provides algorithms and clinical strategies to manage statin intolerance and optimize LDL-C lowering in patients with statin-associated muscle symptoms.
Statins are highly effective for preventing cardiovascular events by reducing low-density lipoprotein cholesterol (LDL-C). However, many patients taking statins report muscle-related symptoms that prevent the use of guideline recommended doses. Patients with reported intolerance to statins have a high risk of cardiovascular events. Clinical strategies that optimize cardiovascular risk reduction through LDL-C lowering need to be applied in patients experiencing intolerable side effects that they attribute to statins. In this paper, the authors review definitions of statin intolerance, propose algorithms to better define statin intolerance, and describe approaches to optimize cardiovascular risk reduction among individuals reporting statin-associated muscle symptoms.
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Rosenson et al. (2017) conducted a review in Statin intolerance and statin-associated muscle symptoms. Clinical strategies and algorithms for statin intolerance was evaluated. This review proposes algorithms to define statin intolerance and describes clinical approaches to optimize cardiovascular risk reduction in patients with statin-associated muscle symptoms.
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