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July 12, 2002Physiological Genomics

Microarray gene expression profiles in dilated and hypertrophic cardiomyopathic end-stage heart failure

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Population

Left ventricular tissues from patients with end-stage heart failure resulting from dilated cardiomyopathy or…

Comparison

Gene expression profiling using an in-house… vs Normal adult heart reference RNA

Design

Preclinical

Authors

JHJuey‐Jen HwangInterventional CardiologyPAPaul D. AllenElectrophysiologyGTGeorge C. TsengUniversity of Pittsburgh

Discussion

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Overview

Findings from DCM/HCM animal models; leaves open translation to human mechanisms or therapies.

Structured PICO

P
Population
Left ventricular tissues from patients with end-stage heart failure resulting from dilated cardiomyopathy (DCM) or hypertrophic cardiomyopathy (HCM) prior to cardiac transplantation
I
Intervention
Gene expression profiling using an in-house spotted cDNA microarray with 10,272 unique clones
C
Comparator
Normal adult heart reference RNA
O
Outcome
Differentially expressed genessurrogate

Microarray gene expression profiling reveals both shared and distinct molecular pathways in end-stage heart failure caused by DCM and HCM.

Cite This Study

Hwang et al. (2002) studied this question.

synapsesocial.com/papers/69fbd68fdf6507d4845ddaaahttps://doi.org/10.1152/physiolgenomics.00122.2001
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