Why the study?
Do dynamic changes in autonomic tone precede the onset of paroxysmal atrial fibrillation?
Population
77 unselected consecutive patients with paroxysmal atrial fibrillation, mean age 58+/-12 years, 63 men and…
Design
Cohort
Follow-up
24 hours
Authors
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Autonomic shifts may precede PAF onset; hypothesis-generating for prediction models, with prospective trials needed before clinical adoption.
Do dynamic changes in autonomic tone precede the onset of paroxysmal atrial fibrillation?
The onset of paroxysmal atrial fibrillation is preceded by specific variations in autonomic tone, characterized by a primary increase in adrenergic tone followed by an abrupt shift toward vagal predominance.
Bettoni et al. (2002) studied this question.
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