Why the study?
Do heart rate variability parameters indicating vagal modulation change prior to the onset of paroxysmal atrial fibrillation in patients with and without structural heart disease?
Do heart rate variability parameters indicating vagal modulation change prior to the onset of paroxysmal atrial fibrillation in patients with and without structural heart disease?
Patients with lone paroxysmal AF demonstrate a significant shift toward vagal predominance prior to arrhythmia onset, a triggering mechanism not observed in patients with structural heart disease.
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May indicate vagal trigger before lone AF; leaves open whether HRV monitoring aids prediction or prevention in practice or trials.
Klingenheben et al. (1999) studied this question.
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